DENTAL IMMUNOSUPPRESSIVE AGENTS 2010
Immunosuppressive
Immunosuppressive drugs drugs Immunosuppressive
Immunosuppressive Drugs
Drugs
O tli
Outline of Lecture Topics: fL t
T i
1. Immune Responses
1
Immune Responses
2. Classes of Immunosuppressive Drugs
Bertram G Katzung, 11th Edition. Chapter 55, pp 963-986.
Immunosuppressive
Immunosuppressive Drugs
drugs g 1. IMMUNE RESPONSES
A. Normal Immune Responses
Protect host from infections, pathogens, and to eliminate disease. Protection from infection and disease is provided by the collaborative efforts of the innate and adaptive disease is provided by the collaborative efforts of the innate and adaptive Immunity.
Immunity
a. The Innate Immune System
First line of defense against an invading pathogen (antigen), induces physical (e.g., skin), biochemical (e.g., complement lysozyme, interferons), and cellular components (neutrophils monocytes macrophages natural killer (NK) and NK‐T components (neutrophils, monocytes, macrophages, natural killer (NK) and NK T cells. b. The Adaptive Immune System
Mobilized by cues by cues from the innate the innate response, when response when innate processes are incapable are incapable of coping with an infection. This system eliminates pathogens by producing specific antibodies, which are effectors of humoral immunity; and the activation of
T‐cells, ‐ which are effectors of cell‐mediated immunity.
B. Abnormal Immune Responses
INAPPROPRIATE responses can lead to tissue damage (e.g., hypersensitivity) or reactivity against self antigens (e.g., autoimmunity);
CONVERSELY, impaired reactivity to appropriate targets (immunodeficiency) may occur and abrogate essential defense mechanisms.
Immunosuppressive Drugs
2. FOUR MAJOR CLASSES
1. Corticosteroids
Prednisone (DELTASONE) and Prednisolone (HYDELTRASOL), Dexamethasone
2. Cytotoxic Agents
Cyclophosphamide, Azathioprine (IMURAN), and Mycophenolate Mofetil (CELLCEPT)
3 T cell Suppressive Agents
3. T‐cell Suppressive Agents
Cyclosporine (SANDIMMUNE) and
Immunosuppressive drugs drugs Immunosuppressive
Immunosuppressive Drugs
Drugs
O tli
Outline of Lecture Topics: fL t
T i
1. Immune Responses
1
Immune Responses
2. Classes of Immunosuppressive Drugs
Bertram G Katzung, 11th Edition. Chapter 55, pp 963-986.
Immunosuppressive
Immunosuppressive Drugs
drugs g 1. IMMUNE RESPONSES
A. Normal Immune Responses
Protect host from infections, pathogens, and to eliminate disease. Protection from infection and disease is provided by the collaborative efforts of the innate and adaptive disease is provided by the collaborative efforts of the innate and adaptive Immunity.
Immunity
a. The Innate Immune System
First line of defense against an invading pathogen (antigen), induces physical (e.g., skin), biochemical (e.g., complement lysozyme, interferons), and cellular components (neutrophils monocytes macrophages natural killer (NK) and NK‐T components (neutrophils, monocytes, macrophages, natural killer (NK) and NK T cells. b. The Adaptive Immune System
Mobilized by cues by cues from the innate the innate response, when response when innate processes are incapable are incapable of coping with an infection. This system eliminates pathogens by producing specific antibodies, which are effectors of humoral immunity; and the activation of
T‐cells, ‐ which are effectors of cell‐mediated immunity.
B. Abnormal Immune Responses
INAPPROPRIATE responses can lead to tissue damage (e.g., hypersensitivity) or reactivity against self antigens (e.g., autoimmunity);
CONVERSELY, impaired reactivity to appropriate targets (immunodeficiency) may occur and abrogate essential defense mechanisms.
Immunosuppressive Drugs
2. FOUR MAJOR CLASSES
1. Corticosteroids
Prednisone (DELTASONE) and Prednisolone (HYDELTRASOL), Dexamethasone
2. Cytotoxic Agents
Cyclophosphamide, Azathioprine (IMURAN), and Mycophenolate Mofetil (CELLCEPT)
3 T cell Suppressive Agents
3. T‐cell Suppressive Agents
Cyclosporine (SANDIMMUNE) and