Why is Curleys wife significant in the novel 'Of Mice and Men'? Curleys wife significant in the novel 'Of Mice and Men' as she sets alot of different themes in the story; 'She had full rouged lips ...her fingernails red..red mules...' This quote gives the reader a sense that she is equiatted with danger. She also represents the theme of loneliness in the novel. Being part of the group of outsiders in the novel. She is a lonely character who uses her beauty: 'full roughed lips' to attract the ranch workers. Another theme Curleys wife sets is the sense of foreboding throughout the whole of the novel. You can tell that George thinks she could be a temptation to Lennie, this is confirmed further on in the novel "her body was thrown forwards and Lennies eyes moved down her body" and "Lennie wached her fascinated" these quotes shows Curleys wife is becoming an increasing danger. Steinbeck also could show Curleys wife as the typical women in that bcentury, she has not been give a name and instead is only known as 'Curleys wife' showing she is not a individual and is a outsider, like many women at that time. Curleys wife is also part of the theme 'dreams', she has the dream of becoming a glamourus movie star. Lennie, George and eventually Candys have the 'American Dream' but Curleys wifes death then shattered these. In conclusion Curley's wife flirtatiousness behhaviour leads to the downfall and ending of both her and Lennie dieing,making her the main subject of the novel.