Coordination Chemistry

Topics: Chemistry, Inorganic chemistry, Boron Pages: 37 (8334 words) Published: September 27, 2012


Coordination compounds are the backbone of modern inorganic and bio-inorganic chemistry and chemical industry. The chemistry of coordination compounds is an important and challenging area of modern inorganic chemistry. During the last fifty years, advances in this area, have provided development of new concepts and models of bonding and molecular structure, novel breakthroughs in chemical industry and vital insights into the functioning of critical components of biological systems. Coordination compounds are of great importance. These compounds provide critical insights into the functioning and structures of vital components of biological systems. Coordination compounds also find extensive applications in metallurgical process, analytical and medicinal chemistry.

The branch of chemistry most closely concerned with the behaviour of metals under conditions relevant to living systems is known as coordination chemistry. This encompasses the chemistry of metals in aqueous media and their interactions with materials such as those encountered within living organisms or used in the formulation of metallopharmaceuticals. The origins of coordination chemistry as a distinct branch of chemistry date back to the beginning of the 20th century and are marked by the award of a Nobel Prize to Alfred Werner in 1913. Among other achievements, Werner established the structure of the compound now know as cisplatin and used in cancer therapy.

Coordination chemistry, which is the center of organometallic and bioinorganic chemistry1, 2, is an important, ever-expanding and challenging area of modern inorganic research3. New models of bonding4 and molecular structure, led to breakthroughs in chemical industry as well as vital insights into the functioning of biological systems5,6.


Organometallic compounds have been known and studied for nearly 200 years, and their unique properties have been widely used to affect synthetic transformations. Organometallic chemistry is typically thought of as a subset of inorganic coordination chemistry, although it also plays a major role in organic and materials chemistries. Organometallics also play smaller but important roles in biological and analytical chemistry. Organometallic chemistry, started as a branch of organic chemistry and with time it incorporated coordination chemistry and has developed into a true multidisciplinary science. In this field a rich harvest of new and previously understood structural types are reaped every year though skilful synthetic programme. This provides obviously strong challenges and therefore, unlimited opportunities.

The coordination compounds have been developed as pharmaceuticals, owing largely to biomimitic and serendipitous nature of drug development, while many organic pharmaceuticals have evolved from natural products. However, nature has provided relatively few inorganic analogues. General, unfamiliarity with inorganic chemistry within the pharmaceutical industry has also favoured testing and development of organic compounds as drugs.

An organometallic molecule is one that contains a metal-carbon bond.Organometallic chemistry is typically thought of as a subset of Inorganic Coordination chemistry. Organometallics also play smaller but important roles in other branches of chemistry such as Biological and Analytical. An "organometallic" compound will be defined as one in which there is a bonding interaction (ionic or covalent, localized or delocalized) between one or more carbon atoms of an organic group or molecule and a main group, transition, lanthanide, or actinide metal atom (or atoms).


Schiff-bases have played an important role in the development of coordination chemistry as they readily form stable complexes with most of the main group, transition and later transition metals.Schiff bases and their structural analogues, as...
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