Comparative Analysis of Paracetamol

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  • Topic: Paracetamol, Ibuprofen, Analgesic
  • Pages : 5 (1111 words )
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  • Published : May 9, 2013
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UV Spectroscopy:
UV spectroscopy is concerned with ranges from 190 to 370 nm. Compound which are colourless absorb radiation in UV range. In both UV as well as visible spectroscopy only the valence electrons absorb the energy there by molecule undergoes transition from ground state to exited state. This absorbance is characteristic and depends on the nature of the electron present. The intensity of the electron depends on the concentration and path length as given by Lambert beer’s law.

Lambert Beer’s law:
According to Beer’s law: The intensity of a beam of monochromatic light decreases exponentially with increase in the concentration of absorbing species arithmetically. According to Lambert’s law: The rate of decrease of intensity (monochromatic light) with the thickness pf medium is directly proportional to the intensity of incident light A = ε . c . t Where A is absorbance (no units, since A = log10 P0 / P ) ε is the molar absorbtivity with units of L mol-1 cm-1

t is the path length of the sample - that is, the path length of the cuvette in which the sample is contained. We will express this measurement in centimetres. c is the concentration of the compound in solution, expressed in mol L-1

INTRODUCTION OF PARACETAMOL :

Paracetamol (325mg), a non-opioid and non-salicylate analgesic. It is indicated for the treatment of moderate to severe pain.

NameAcetaminophen
Drug TypeSmall Molecule
Approved
DescriptionAnalgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage. SynonymsAcetaminofen

Paracetamolo
Paracetamol
Brand TakenCrocin - Remidex Pharma
Calpol - GlaxoSmithKline
P-500 - Apex Labs
Pyrigesic - East India Pharmaceuticals
Pacimol - Ipca Labs
Paracin - Torque Pharmaceuticals
Dolo-500 - Micro Labs
T-98 - Mankind Pharma
Paracip - Cipla Pharmaceuticals
Algina - Geno Pharmaceuticals
Chemical IUPAC NameN-(4-hydroxyphenyl)acetamide
Chemical FormulaC8H9NO2
Chemical Structure
Experimental Water Solubility14 mg/mL (very slightly soluble in cold water; considerably more soluble in hot water) Pharmacokinetic dataBioavailability
~100%
Metabolism
90 to 95% Hepatic

Half life
1–4 h
Excretion
Renal

Average Molecular Weight151.1626 g/mol
Melting Point169-170.5°C
Predicted Water Solubility4.15e+00 mg/mL
StateSolid
Experimental LogS-1.03S
Drug CategoryAnalgesics, Non-Narcotic
Antipyretics
IndicationFor temporary relief of fever and minor aches and pains. AbsorptionRapid and almost complete

Paracetamol or acetaminophen is a widely used over-the-counter analgesic (pain reliever) and antipyretic (fever reducer). It is commonly used for the relief of fever, headaches, and other minor aches and pains, and is a major ingredient in numerous cold and flu remedies. In combination with non-steroidal anti-inflammatory drugs (NSAIDs) and opioid analgesics, paracetamol is used also in the management of more severe pain. Paracetamol is derived from coal tar, and is part of the class of drugs known as “aniline analgesics”; it is the only such drug still in use today. It is the active metabolite of phenacetin, once popular as an analgesic and antipyretic in its own right, but unlike phenacetin and its combinations, paracetamol is not considered to be carcinogenic at therapeutic doses. History

The first observations about the analgesic and antipyretic properties of paracetamol were made back in the late nineteenth century when alternative compounds were being sought to reduce fever in the treatment of infections. The antipyretics commonly used at the time consisted of preparations of natural compounds such as cinchona bark, from which quinine is derived, or galenicals...
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