"Boom Boom" is an uptempo stop-time blues song that does not follow a typical twelve-bar blues pattern. "Hooker's sense of timing was his and his alone, demanding big-eared sidemen". Backing John Lee Hooker (vocal and guitar) are members of the Funk Brothers (Joe Hunter (piano), James Jamerson (bass), and Benny Benjamin (drums)); plus Larry Veeder (guitar), Hank Cosby (tenor saxophone), and Andrew "Mike" Terry (baritone saxophone).
The song became a hit, reaching #16 in the Billboard R&B chart where it spent eight weeks in 1962. "Boom Boom" also made an appearance in the US pop chart (1962 at #60), one of only two Hooker singles to do so. Thirty years later, after being featured in a Lee Jeans commercial in 1992, the song reached #16 in the UK Singles Chart. In 1995, the song was included in the Rock and Roll Hall of Fame's list of "The Songs That Shaped Rock and Roll". "Boom Boom" was inducted into the Blues Foundation Hall of Fame in 2009 in the "Classics of Blues Recording" category.