Biopharm

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BIOPHARMACEUTICS

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In LADMER system, L stands for liberation as the first step which determines the following aspects, except: a. onset of action c. rate of absorption b. type of preparation d. bioavailability

The ultimate evaluation of dosage forms or delivery system is in: a. disintegration time c. clinical effectiveness b. thickness d. taste

Factor that contributes to patient’s difference in drug concentration in the body, except: a. body weight c. age
b. obesity d. climate

A rate limiting factor in the dissolution of drugs is:
a. disintegration of the tablet c. content uniformity
b. thickness d. local effect

The effect of reduced particle size of a drug is:
a. increased absorption c. increased hardness
b. increased disintegration d. all of them

A cause of patient to patient variability of time course of the drug in the plasma is: a. disease c. genetic in origin
b. concomitant drug therapy d. all of the above

Dissolution rate tests can be used to predict bioavailability if: a. dissolved drug remains free in the GIT
b. dissolved drug is decomposed in the GIT
c. drug is hydrolyzed in the GIT
d. all of them

Elimination half-life of a drug is the time in hours needed to reduce drug concentration to: a. half of the parent drug c. all or taken dose b. one fourth of the initial dose d. a & b

Tmax means:
a. time of great solubility of the drug
c. time of peak concentration
b. peak height concentration
d. AUC values

D

D

D

B

D

10. To generally increase the solubility of a poorly soluble drug in an aqueous medium, the process is: a. complexation c. prepare into a derivative b. adsorption d. a & c

11. The ionization constant of a drug is important in bioavailability since it determines the following, except: a. its aqueous solubility c. pH of the medium b. dissolution rate d. extent of protein binding

12. The difference in bioavailability of a drug product of the same therapeutic agent is due to: a. difference in formulation ingredients c. difference in methods of manufacture b. difference in packaging d. a & c

13. Which of the crystal forms give the best dissolution rate? a. meta-stable polymorph c. stable polymorph b. amorphous d. a and b

14. The termination of action of a drug is determined by:

a. excretion of intact active molecule
b. excretion of active molecule

c. tissue redistribution
d. a & c

D

D

15. Pharmaceutical equivalents are drug products that contain: a. identical amounts of active drugs
b. identical amounts of inactive ingredients
c. identical amounts of excipients
d. all of the above

16. The purpose of biotransformation reaction is:

a. deactivate the drug
b. preserve the drug from destruction

c. promote elimination of inactive drug
d. a & c

D

17. The advantage of sublingual/buccal administration is:

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BIOPHARMACEUTICS

a. no occurrence of gastrointestinal degradation
b. drug directly in the circulation
c. not pass to the liver
d. a & c

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18. The integral of the drug level over time from zero to infinity is: a. biologic half-life c. bioavailability
b. area under the curve d. biopharmaceutics

19. The rate and extent at which the drug appears in the bloodstream is known as: a. biopharmaceutics c. bioavailability
b. area under the curve d. biologic half-life

20. An inactive or much...
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