Bio Dna History

Topics: DNA, Francis Crick, Rosalind Franklin Pages: 2 (401 words) Published: January 13, 2013
History of DNA WebQuest
1. Friedrich (Fritz) Miescher Find Miescher on the timeline and click on the bucket with the Red Cross to watch the animation.  In 1869, he extracted a substance from white blood cells that he called nuclein.  What do you think he was actually extracting?   

2. Frederick Griffith Frederick Griffith’s famous experiment was conducted in 1928. In his experiment, ______________ smooth virulent bacteria plus live rough _____________________ bacteria killed mice.  His experiment demonstrated that DNA was the ____________ material.     

Griffith’s Famous Experiment: Transformation
3. Oswald Avery: In 1944, what did he discover that DNA is responsible for?   
4.  Alfred Hershey and Martha Chase:
a. In 1952, their experiments showed that ______ is the genetic material instead of ____________. 

5. Erwin Chargaff:
Watch “Chargaff’s Ratios.”  Chargaff used relative proportions of bases in DNA to come up with his rules for base pairing.  What are four sources of DNA that he used? Adenine (A) pairs with _____________
Guanine (G) pairs with _____________
The bases that are purines include ___________ & ____________. The bases that are pyrimidines include __________ & ____________.  

6. Rosalind Franklin: Watch Franklin’s X-ray diffraction pattern. What is X-ray crystallography (a.k.a. X-ray diffraction)?  
What did she discover about the shape of DNA?

7. Linus Pauling:...
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