Fischer and Von Mering were the first duo to create a therapeutically active barbiturate. They got this compound by substituting two ethyl groups for two hydrogens attached to a carbon. This substance was found to induce sleep. This type of sleep aid is called somnolent or hypnotic.
There is a mix up on how the drug got its name. There are two versions one is that when they found out they made the substance they were in Verona. And the other is that the drug relaxes the mind just like Verona. The problem with this drug was that it took a long time to take effect and to wear off so many people did not like it. So they tried to make it more efficient so that it would start working faster and wear off in a shorter amount of time. This substance was used as anesthesia before surgery. The short acting barbiturates are called evipal, thiopental, and brevital. Widely known barbiturates are Valium and Halicon.
Benzodiazepines have replaced barbiturates in therapy except in anesthesia. In today’s world the most common one is phenobarbitol because it is cheap.
In general they are known as brain relaxers, in the same type of effect as alcohol. In small doses the person feels drowsy, disinhibited, and intoxicated. In higher doses the person staggers, slurred speech, and confused. At even higher doses the person can fall into a coma or even death.
The difference of dosage is a narrow...