Ashitaba

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Lipid Lowering Potential of the Crude Ethanolic Extract of Gynura nepalensis (Ashitaba) in Hyperlipidemic Mice

Chapter 1
INTRODUCTION
Hyperlipidemia is the elevation of fasting blood triglyceride and cholesterol concentrations. This condition may be inherited or may be a consequence of another disorder such as hypothyroidism, alcohol dependence, kidney failure, and diabetes mellitus and can also raise the risk for heart disease, heart attack, and stroke. It is not an illness itself but merely a condition that can be linked to serious diseases and can be prevented by lifestyle modification and medications. Cases of hyperlipidemia in the Philippines increase spontaneously in the recent years. Current advances and developments in technology made it more convenient and easy for researchers to identify and analyze the therapeutic properties of a plant material that can be valuable in modern medicine. Several articles had cited plants that can help lower lipid level in the blood. Gynura nepalensis DC (Ashitaba) is one of them. Gynura nepalensis DC is the ashitaba grown in the Philippines. It is also called Gynura procumbens and Gynura acutifolia. Ashitaba (Angelica keiskei Kodzumi) is the ashitaba which originated in the Island of Hachijo, Japan. (Ursulom, 2013). Both ashitaba (Gynura nepalensis and Angelica keiskei Kodzumi) have been claimed to be anti-oxidant, anti-cancer, anti-aging, anti-inflammatory, antihypertensive, and antidiabetic. Furthermore, it can treat disorders like cough, asthma, kidney stones, urinary tract bleeding, hepatitis, gall bladder stones, hemorrhoids, constipation, diarrhea, vomiting, blood poisoning, septicemia, fertility problems, external wounds, skin allergy, rheumatism, high cholesterol levels, high-low blood pressure, and diabetes. It also suppresses growth of cancer cells, aids in more balanced blood cells and helps in the recovery of bone injuries. (Ursulom, 2013) Statement of the Problem

The study aims to determine the...
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