The leaves of Chromolaena odarata (commonly called siam weed) which is an ancient remedy for the treatment of wounds and many ailments was tested for its antimicrobial activities on staphylococcus aureus and Escherichia coli at different concentrations. The agar pour plate method was used to test for its antimicrobial activity on the test isolate, the extracts of Chromolaena odorata was introduced directly into the well of the two tested organism. Laboratory study,shows that Chromolaena odorata (Siam weed) has antimicrobial action against these organisms. This research work establishes a good support to the use of these plants in herbal and as base for development of new drugs.
INTRODUCTION CHROMOLEANA ODORATA (SIAM WEED)
Chromoleana odorata (commonly called siam weed),is a diffuse rapidly growing and strongly scenting perennial shrub (phan,et al 2001).It grows widely in the south and western part of Nigeria, as well as in other parts of west Africa. The plant is used by traditional medicine practitioners in the treatment of many aliments (Gill, 1992).Some of the traditional uses of the leaves of this plant includes treatment of dysentery and headache. The concoction of the leaves with Azadracta indica, is used for the treatment of malaria fever. The juice of the leave (sometimes mixed with water) is used to stop bleeding. The healing property of the medicinal plants is usually linked with the presence of secondary metabolites and these differ from one plant to another. It has been reported that a substantial percentage (38%) of prescriptions, contained one or more of the natural product of plant origin, as the therapeutic agent (Farnsworth and bringel, 1997). The use of plant extracts chemically derived from plants to treat diseases has stood the test of time (Anwannil and atta, 2005). Suck(1989),had earlier reported that more than 75% pure compounds derived from higher plants are used in modern medicine and are now produced synthetically. In recent studies, extract of the various parts of the medicinal plants were found to have brought spectrum antimicrobial activities against pathogenic organisms (Sudhaka, et. al, 2006) (Khan et. al, 2006). BACKGROUND OF STUDY
Medical plants have contributed greatly to health care in Nigeria. This is due to the recognition of the value of traditional medicine system, particularly in Nigeria origin, and the identification of medicinal plants from local pharmacopoeias, which form significant healing power. This project work is basically concerned with the antimicrobial activity of chromolaena odorata on Staiphylococus aureus and Escherichia coli, since they have been known to be responsible for different diseases in man. The staphylococcus genus include 31 species, most of which are harmless, and resides normally on the skin and mucus membrane of humans and other organism found worldwide. They are small component of soil microbial flora (Holk; J.G. 1994). Escherichia coli is a bacterium that is commonly found in the lower intestine of warm blooded animals. Most Escherichia coli strains are harmless, but some strains like serotype; 0157: H7 can cause serious food poisoning in humans. The harmless strains apart from the normal floral of the gut, can benefit from their host by producing vitamin K2, or by preventing the establishment of pathogenic bacteria within the intestine (Vogt R.L. Dippold 2005). PURPOSE OF THE STUDY
The aim and objectives of this project work are:
i.To know if the leave extracts of chromolaena odorata will be inhibitory to the growth of Staphylococcus aureus and Escherichia coli. ii.To evaluate the antimicrobial activity of the plant extracts. iii.To be able to recommend the use of this plant as treatment therapy. SIGNIFICANCE OF THE STUDY
The significance of this work is to:
i.Show the antimicrobial activity of the plant
ii.Establish a good support to the use of the plant in herbal medicine and as a...