Anti-ulcerogenic evaluation of the ethanolic extract of water spinach (Ipomoea aquatica Forsk) in aspirin ulcerated rats. Dhanasekaran.Sivaraman*1 and Palayan.Muralidaran1 *1 Department of Pharmacology and Toxicology,C.L.Baid Metha College of Pharmacy,Jyothi Nagar,Thoraipakkam,Chennai 97,Tamil Nadu,India For correspondence:Dhanasekaran.Sivaraman,Department of Pharmacology and Toxicology,C.L.Baid Metha College of Pharmacy,Jyothi Nagar,Thoraipakkam,Chennai 97,Tamil Nadu,India. E-mail: email@example.com. Received on: 29-08-2008; Accepted on :10-09-2008 ABSTRACT Aim of the study is to evaluate the anti-ulcer efficacy of the Ipomoea aquatica Forsk (IAF), is known to possess various therapeutic properties. The reason for the study is that, the known non-steroidal anti-inflammatory drugs (NSAIDs) are full of side effects especially ulceration which is at the top. Gastric ulceration is a cause of economic loss and a source of welfare concern worldwide. There are 350,000 to 500,000 new cases per year and more than one million ulcer-related hospitalizations each year. We found that IAF decreased the incidence of ulcers and also enhanced the healing of ulcers. Ethanolic extract of IAF at a dose of 200 and 400 mg/kg was found to be effective by (68.72%) for 200mg/kg and (62.13%) for 400mg/kg in aspirin (ASP) induced ulcer model and significantly reduced free and total acidity; we observed that anti-ulcer effect of IAF may be due to its cytoprotective effect rather than antisecretory activity. Conclusively, IAF was found to possess potent anti-ulcerogenic as well as ulcer-healing properties and could act as a potent therapeutic agent against peptic ulcer disease. Key Words : Ipomoea aquatica Forsk; Peptic ulcer; Aspirin; Non-steroidal anti-inflammatory drugs
1. INTRODUCTION Ipomoea aquatica Forsk belongs to the family Convolvulaceae grows wild and is cultivated throughout Southeast Asia and is a widely consumed vegetable in the region. Many of the...
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