Allerfin Chlorpheniramine Maleate

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ALLEFRIN

Chlorpheniramin maleate

Properties: Allefrin (Chlorpheniramine maleate) has a very good therapeutic efficacy as histamine antagonizing agent with a very low incidence of side effects. It is one of the best effective antihistamines, although administered in a very low dosage which is far below any that are toxic.

Its medical actions are due to the following pharmacological properties:

a. It antagonizes the action of histamine on the plain muscles of the bronchioles, intestine and bladder,

b. It antagonizes both vasodilator and vasoconstrictor actions of histamine on the blood vessels,

c. It prevents the dilatation and increased permeability produced by histamine on the capillaries and reduces the wheal caused by intradermal injection of histamine.

Indications: Allefrin (Chlorpheniramine maleate) is used in:

- Allergic manifestations such as vasomotor rhinitis and hay fever.

- Spasmodic bronchial cough without dyspnea especially when cough preparations may prevent sleep, unless combined with sedatives. Furthermore, it can useful as a complete alternative for cough preparation s at night.

- Urticaria and angioneurotic edema.

- Serum sickness and motion sickness (antiemetic).

- Reactions from penicillin, streptomycin, sulphonamides and other drugs.

- Pruritis ani and vulvae.

- Atopic and contact dermatitis and insect bites.

- In prevention and treatment of systemic allergic reaction to injections of allergenic substances.

Precautions: This drug may produce mild sedation and it is advised that patients under continuous treatment should be examined periodically. And they have to avoid operating machinery.

Dosage:

Tablets: Adults: one tablet, 3-4 times daily

Syrup: Children: ½-1 tspful, 3-4 times daily.

Ampules: Adults: 10-20 mg by intramuscular or subcutaneous injection. For severe allergies. Allerfin ampules can be also used by intravenous...
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