This textbook was made possible by an unrestricted educational grant provided by Bernd Sebastian Kamps and Patricia Bourcillier.
From basic science to patient care
Juan Carlos Palomino Sylvia Cardoso Leão Viviana Ritacco
Juan Carlos Palomino Mycobacteriology Unit Institute of Tropical Medicine Nationalestraat, 155 20000, Antwerp BELGIUM Sylvia Cardoso Leão Departamento de Microbiologia, Imunologia e Parasitologia Universidade Federal de São Paulo Rua Botucatu, 862 3° andar 04023-062, São Paulo, SP BRAZIL Viviana Ritacco Servicio de Micobacterias, Instituto Nacional de Enfermedades Infecciosas Carlos G. Malbrán Av. Velez Sarsfield, 563 1281, Buenos Aires ARGENTINA Cover design by Pedro Cardoso Leão, BRAZIL (firstname.lastname@example.org)
Tuberculosis is an ever-changing field. The editors and authors of “Tuberculosis 2007 – from basic science to patient care” have made every effort to provide information that is accurate and complete as of the date of publication. However, in view of the rapid changes occurring in medical science, as well as the possibility of human error, this site may contain technical inaccuracies, typographical or other errors. Readers are advised to check the product information currently provided by the manufacturer of each drug to be administered to verify the recommended dose, the method and duration of administration, and contraindications. It is the responsibility of the treating physician who relies on experience and knowledge about the patient to determine dosages and the best treatment for the patient. The information contained herein is provided "as is" and without warranty of any kind. The contributors to this site disclaim responsibility for any errors or omissions or for results obtained from the use of information contained herein. Proofreading: Emma Raderschadt © 2007
This book is the result of a joint effort in response to the Amedeo Challenge to write and publish a medical textbook on tuberculosis. This non-profit-making initiative is particularly attractive due to several reasons. First, the medium chosen for dissemination: the book will be readily available on the internet and access will be free to anyone. Second, its advantage over books published via traditional media is the ease to update the information on a regular basis. Third, with the exception of Spanish and Portuguese, no copyright is allocated and the translation of Tuberculosis 2007 to all other languages is highly encouraged. These innovations in the way of publication were translated to the organization of the chapters in the book. This is not a classical textbook on tuberculosis diagnosis, management, and treatment. On the contrary, it is a multidisciplinary approach addressing a full range of topics, from basic science to patient care. Most authors are former members of RELACTB – a Tuberculosis Research Network for Latin America, the Caribbean and Europe sponsored by the United Nations University − and have worked on collaborative projects since 1995. Classical knowledge about the disease is focused on chapters dedicated to the history of tuberculosis, microbiology of the tubercle bacillus, description of the disease caused by Mycobacterium tuberculosis complex members in adults, children, and HIV/AIDS patients, conventional epidemiology, diagnostics, biosafety, and treatment. More recent findings, which have changed our knowledge about tuberculosis in the last years, are detailed in chapters on the molecular evolution of the M. tuberculosis complex, molecular epidemiology, host genetics, immune response and susceptibility to tuberculosis, studies on the pathogenesis of tuberculosis in animal models, and new diagnostic and drug resistance detection approaches. Perspectives for future...