Most Interesting Person I Have Ever Met

Only available on StudyMode
  • Download(s) : 5338
  • Published : April 16, 2013
Open Document
Text Preview

Chemicals

SAMPLE NAME: Paracetamol Tablets
ANALYSIS REQUIRED: Paracetamol
CLAIM: Each tablet contains 500mg Paracetamol.
THEORY:
Paracetamol
IUPAC Name: N-(4-hydroxyphenyl)ethanamide N-(4-hydroxyphenyl)acetamide Molecular Formula: C8H9NO2
Chemical Structure:
Paracetamol INN or acetaminophen USAN is a widely used over-the-counter analgesic (pain reliever) and antipyretic (fever reducer). It is commonly used for the relief of headaches and other minor aches and pains and is a major ingredient in numerous cold and flu remedies. In combination with opioid analgesics, paracetamol can also be used in the management of more severe pain such as post-surgical pain and providing palliative care in advanced cancer patients. The onset of analgesia is approximately 11 minutes after oral administration of paracetamol, and its half-life is 1–4 hours. Though acetaminophen is used to treat inflammatory pain, it is not generally classified as an NSAID because it exhibits only weak anti-inflammatory activity. PROCEDURE:

* Weighed 10 tablets and calculated the average weight of 1 tablet. * Calculated the sample to be taken according to the claim. * Crushed the tablets in a pestle and mortar.
Preparation of the Test Dilution:
* Weighed around 86 mg of the sample.
* Transferred the sample in a 100 ml volumetric flask.
* Made up the volume to 100ml with 0.1N NaOH.
* Transferred 2 ml of the above solution in a 100 ml volumetric flask. * Made up the volume to 100 ml with 0.1N NaOH.
* Filtered the above solution in a test tube.
Preparation of the Standard Dilution:
* Weighed about 51 mg of the standard.
* Transferred it in a 100 ml volumetric flask.
* Made up the volume to 100 ml with 0.1N NaOH.
* Transferred 2 ml of the above solution in a 100 ml volumetric flask. * Made up the volume to 100 ml with 0.1N NaOH.
* Filtered the above solution in a test tube.
For the measurement of the OD:
* Started the Spectal Manager Software, Clicked on Spectral Measurement. * Filled both the cuvettes with 0.1N NaOH.
* Clicked on Baseline Measurement to set 0.1N NaOH as Blank. * Filled the outer cuvette with the Standard Dilution.
* The OD was taken by clicking on Sample Measurement.
* Filled the outer cuvette with the Test Dilution.
* The OD was taken by clicking on Sample Measurement.

OBSERVATIONS:

Figure: Sample(Paracetamol)

Figure: Filtration of the Standard and Test Dilutions.
OD of the standard dilution: 0.7576
OD of the sample solution: 0.7100
CALCULATIONS:
Weight of 10 tablets: 5.7665 g
Average Weight: Weight of 10 tablets10
= 5.766510
= 576.65 mg
Weight of the sample to be taken: Awerage Weight×Equivalent WeightClaim = 50×576.65500
= 57.6 mg
Weight of the sample taken: 58.1 mg
Weight of the standard taken: 51.1 mg
Paracetamol Content Present: OD of Sample×Dilution of Standard×Potency×Awerage Weight of the sampleOD of Satndard×Dilution of Sample = 0.7100×51.1×2×100×100×0.995×576.650.7576×100×100×58.1×2 = 472.9 mg

Percent of Paracetamol Present in the sample: Calculated Paracetamol Content×100Claim = 472.9×100500
= 94.58%
RESULT: The sample was passed and can be marketted.
SAMPLE NAME: Povidone-Iodine Solution (Microbicidal Solution) ANALYSIS REQUIRED: Povidone Iodine.
CLAIM: Each 1 ml contains 0.5 IU Povidone-Iodine.
THEORY:
Povidone Iodine
IUPAC Name: 2-Pyrrolidinone, 1-ethenyl-, homopolymer, compd. with iodine. Molecular Formula: C6H9NO)n
Chemical Structure:
Povidone-iodine (PVP-I) is a stable chemical complex of polyvinylpyrrolidone (povidone, PVP) and elemental iodine. It contains from 9.0% to 12.0% available iodine, calculated on a dry basis. This unique complex was discovered at the Industrial Toxicology Laboratories in Philadelphia by H. A. Shelanski and M. V. Shelanski. They carried out tests in vitro to demonstrate anti-bacterial activity, and found that the complex was less toxic than tincture of iodine in mice....
tracking img