Embryo Culture: Methods and Advancements

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METHODS

IN

MOLECULAR BIOLOGY™

Series Editor John M. Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK

For further volumes: http://www.springer.com/series/7651

Embryo Culture
Methods and Protocols
Edited by

Gary D. Smith
University of Michigan, Ann Arbor, MI, USA

Jason E. Swain
University of Michigan, Ann Arbor, MI, USA

Thomas B. Pool
Fertility Center of San Antonio, San Antonio, TX, US

Editors Gary D. Smith University of Michigan Ann Arbor, MI, USA Thomas B. Pool Fertility Center of San Antonio San Antonio, TX, USA

Jason E. Swain University of Michigan Ann Arbor, MI, USA

ISSN 1064-3745 ISSN 1940-6029 (electronic) ISBN 978-1-61779-970-9 ISBN 978-1-61779-971-6 (eBook) DOI 10.1007/978-1-61779-971-6 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2012941744 © Springer Science+Business Media, LLC 2012 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is a brand of Springer Springer is a part of Springer Science+Business Media (www.springer.com)

Preface
Assisted reproductive technologies have had a profound impact on biomedical research through transgenic animals, food supply and production, as well as genetic gain of domestic species, and treatment of human infertility. Understanding regulatory pathways of early mammalian embryo development, preimplantation embryo cellular differentiation, and pluripotency of the embryonic inner cell mass has been pivotal to advances in embryo culture, transgenic mouse production, and biomedical advances in basic research, understanding the pathophysiology and progression of diseases, and development of novel treatments and cures. In 2007, Drs. Capecchi, Evans, and Smithies were awarded the Nobel Prize in Physiology or Medicine for their groundbreaking discoveries in relation to utility of embryonic stem cells, DNA recombination, and refinement of gene targeting in mice. Central to transgenic animal technology is mammalian embryo culture. While assisted reproductive technologies for the treatment of infertility can be controversial and have a relatively brief lifespan, they have also touched many families’ lives in very positive ways. The pioneering utility of assisted reproductive...
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