Article Review: Effectiveness of Lithium in Children and Adolescents

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Article Review: Effectiveness of Lithium in Children and Adolescents

By | Feb. 2013
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Date: 2/5/2013Name: Andrew Iraheta, Josh Tran
APA Style Reference. Masi, G., Milone, A., Manfredi, A., Pari, C., Paziente, A., & Millepiedi, S. (2009). Effectiveness of lithium in children and adolescents with conduct disorder. CNS Drugs 23 (1), 59-69. doi: 10.2165/0023210-200923010-00004.| Rationale for the study. There have been varying results that question the effectiveness of Lithium as a treatment for Conduct Disorder. Some studies claimed positive results in treating severe cases Conduct Disorder, but these studies are scarce so further study is needed. The Rationale for this study was to find out the effectiveness of treating Conduct Disorder in children/adolescents with Lithium and identify the positive and/or negative effects that come from this treatment.| Hypotheses / Research Questions. The research was to identify if Lithium was an effective monotherapy treatment for conduct disorder. Lithium or in combination with atypical antipsychotics was explored to identify the negative and positive responses to the treatments. Children and adolescents were examined to determine the effects and tolerability of these treatments.| The Independent Variables for this study were the Lithium monotherapy, Psychostimulants, atypical antipsychotics, and SSRI’sThe Dependent Variables were the children/adolescents’ levels of aggression, as well as behavior in general, and their global assessment of functioning. In terms of predictors the study emphasizes that these are highly debated and can vary greatly. However the study claims that predatory and profitable aggression make patients more likely to be resistant to medication.| Findings Lithium monotherapy treatment improved significantly with exception of self-aggression (p.89). Patients who took lithium along with atypical antipsychotic therapy improved significantly (p/= .80. Between the two treatments, baseline clinical severity and functional impairment assesments indicate no...
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